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KMID : 1234920120120020028
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Journal of Korean Oriental Association for Study of Obesity
2012 Volume.12 No. 2 p.28 ~ p.43
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Impact of GNB3, ADRB3, UCP2, and PPARγ-Pro12Ala polymorphisms on Boiogito response in obese subjects : A randomized, double-blind, placebo-controlled trial
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Park Jung-Hyun
Shambhunath Bose
Lim Chi-Yeon
Kim Ho-Jun
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Abstract
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Objectives: The aim of the study was to investigate the efficacy of Boiogito for obesity. We examined the efficacy of Boiogito for obese patients and we expected the reaction of Boiogito would vary according to the single nucleotide polymorphism(SNPs).
Methods: 111 subjects(body mass index≥25m/kg2) were recruited and randomized to receive Boiogito(n=55) or Placebo(n=56) for 8weeks. Anthropometric factors, serum lipid profile, glucose, blood pressure(BP), pulse rate, resting metabolic rate and Korean version of obesity-related quality of life(KOQOL) scale measured at baseline and 8weeks. SNPs(β3-adrenergic receptor(ADRB3), G protein β3(GNB3), peroxisome proliferator activated receptor gamma 2 gene(PPAR-γ2), uncoupling protein(UCP2)) were conducted at baseline. Adverse reactions and safety outcome variables were also checked during trials.
Results: Both groups showed significant improvement on obesity after treatment. Boiogito group decreased triglyceride than did control group and improved KOQOL. Boiogito showed a significant higher efficacy in C/T and T/T genotype of GNB3 gene / in Trp64 and Arg64 genotype of ADRB3 gene / in D/D genotype of UCP2 gene / in Pro/Pro genotype of PPAR-γ gene.
Conclusions: Boiogito promoted obesity indexes without severe adverse reactions and proved its safety. Pharmacogenetical studies of Boiogito on obesity could be a effective method for the individualized treatment and prevention of obesity.
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KEYWORD
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Boiogito, obesity, SNPs, RCT
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